Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.8
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Zinc (as Zinc bisglycinate)
30 mg
273%
Top Medical Research Studies
8
We explored how zinc affects blood clotting, particularly through a substance called Zn@SiO nanocomposite. This material shows promise as a hemostatic agent, which means it helps stop bleeding by promoting the formation of stable blood clots.
During our analysis, we examined various aspects of how this nanocomposite interacts with blood. It activates specific factors in the coagulation cascade—the process our bodies use to form clots. With the presence of zinc in the material, we observed enhanced activation of these factors, leading to improved clot formation.
Our research involved synthesizing and characterizing the Zn@SiO nanocomposite using several methods, including XRD, FTIR, and HRTEM. We also tested its effects on red blood cell aggregation, platelet adhesion, and several vital clotting time measures. The results indicate that Zn@SiO has significant hemostatic properties, showing potential for use in surgeries and trauma care.
This study highlights the exciting role of zinc in optimizing hemostasis, making it a candidate worth considering for medical applications related to bleeding management.
During our analysis, we examined various aspects of how this nanocomposite interacts with blood. It activates specific factors in the coagulation cascade—the process our bodies use to form clots. With the presence of zinc in the material, we observed enhanced activation of these factors, leading to improved clot formation.
Our research involved synthesizing and characterizing the Zn@SiO nanocomposite using several methods, including XRD, FTIR, and HRTEM. We also tested its effects on red blood cell aggregation, platelet adhesion, and several vital clotting time measures. The results indicate that Zn@SiO has significant hemostatic properties, showing potential for use in surgeries and trauma care.
This study highlights the exciting role of zinc in optimizing hemostasis, making it a candidate worth considering for medical applications related to bleeding management.
Read More
8
We observed a significant advance in our understanding of how zinc therapy can affect blood clotting, particularly with a compound called rutin. This study explored how zinc ions can be combined with rutin to enhance its aqueous solubility and therapeutic potential.
Rutin, a natural flavonoid found in various plants and foods, has been known for its ability to inhibit a protein called protein disulfide isomerase (PDI), which plays a role in blood clotting. However, we encountered challenges with rutin’s low solubility in water, which limits its effectiveness in therapeutic settings.
In this study, we found that when we chelated zinc ions with rutin, the resulting rutin:Zn complex showed a remarkable fourfold increase in solubility. More excitingly, this complex also exhibited a stronger inhibition of PDI activity compared to rutin alone.
In further testing with a murine model designed to induce arterial thrombosis, the rutin:Zn complex demonstrated a notable ability to slow down arterial occlusion without increasing bleeding risks. This suggests that zinc not only aids in solubility but also enhances the anti-thrombotic properties of rutin.
Overall, our findings indicate that combining zinc with certain flavonoids could be a promising strategy for elevating their benefits in combating blood clots.
Rutin, a natural flavonoid found in various plants and foods, has been known for its ability to inhibit a protein called protein disulfide isomerase (PDI), which plays a role in blood clotting. However, we encountered challenges with rutin’s low solubility in water, which limits its effectiveness in therapeutic settings.
In this study, we found that when we chelated zinc ions with rutin, the resulting rutin:Zn complex showed a remarkable fourfold increase in solubility. More excitingly, this complex also exhibited a stronger inhibition of PDI activity compared to rutin alone.
In further testing with a murine model designed to induce arterial thrombosis, the rutin:Zn complex demonstrated a notable ability to slow down arterial occlusion without increasing bleeding risks. This suggests that zinc not only aids in solubility but also enhances the anti-thrombotic properties of rutin.
Overall, our findings indicate that combining zinc with certain flavonoids could be a promising strategy for elevating their benefits in combating blood clots.
Read More
9.5
We explored the effects of a newly discovered fibrinolytic enzyme from the marine fungus Penicillium steckii KU1, particularly its interaction with zinc in the context of blood clot dissolution. This enzyme, which has a molecular weight of 12.6 kDa, is a plasmin-like protein that becomes more active in the presence of zinc. While it effectively dissolves blood clots, achieving complete dissolution in just 30 minutes with a specific concentration, we also observed that its activity is significantly inhibited by certain agents like EDTA.
Interestingly, the enzyme demonstrated a low level of hemolysis at just 2.60%, indicating that it could be a safer alternative for thrombolytic therapy. However, it's important to note that while zinc enhances the enzymatic activity, the isolated effects of zinc on blood clot breakdown remain somewhat unclear due to the enzyme's overall presence.
This research highlights the potential of the marine-derived enzyme and the role of zinc, suggesting that further studies could provide deeper insights into improving thrombolytic treatments. These findings could be significant for enhancing the safety and effectiveness of therapies designed for clot management.
Interestingly, the enzyme demonstrated a low level of hemolysis at just 2.60%, indicating that it could be a safer alternative for thrombolytic therapy. However, it's important to note that while zinc enhances the enzymatic activity, the isolated effects of zinc on blood clot breakdown remain somewhat unclear due to the enzyme's overall presence.
This research highlights the potential of the marine-derived enzyme and the role of zinc, suggesting that further studies could provide deeper insights into improving thrombolytic treatments. These findings could be significant for enhancing the safety and effectiveness of therapies designed for clot management.
Read More
Most Useful Reviews
2
Weakens stomach often
2 people found this helpful
Zinc hinders viral growth in the throat and respiratory tract, increasing blood leukocyte production which combats bacteria and viruses. This supplement is effective at the first sign of a cold but has a major drawback: it often irritates the stomach, causing discomfort after meals or on an empty stomach. I found another brand that doesn't have these side effects and would not recommend this one.
Read More
9
Significant health improvement
1 people found this helpful
After taking this supplement for a month, I've seen a notable improvement in my overall health. My immune system has strengthened as I haven't caught a cold or flu since starting it. Additionally, my blood clotting has improved, allowing for quicker healing of minor cuts and wounds. My hair feels thicker, and my skin appears clearer and brighter. It's a great quality product for enhancing overall health!
Read More
6
Supports immunity well
4 people found this helpful
An excellent form of zinc, it is chelated and absorbed effectively. We take one capsule daily during cold season with meals; on an empty stomach, it may cause headaches. We limit usage to a month and monitor zinc levels with blood tests to avoid excess. It aids immunity and reduces acne due to its anti-inflammatory properties. Recovery with zinc is quicker. Alongside C and D3, I boost mine and my family's immunity. Stay healthy and happy!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.8
- All Researches
9.5
We explored the effects of a newly discovered fibrinolytic enzyme from the marine fungus Penicillium steckii KU1, particularly its interaction with zinc in the context of blood clot dissolution. This enzyme, which has a molecular weight of 12.6 kDa, is a plasmin-like protein that becomes more active in the presence of zinc. While it effectively dissolves blood clots, achieving complete dissolution in just 30 minutes with a specific concentration, we also observed that its activity is significantly inhibited by certain agents like EDTA.
Interestingly, the enzyme demonstrated a low level of hemolysis at just 2.60%, indicating that it could be a safer alternative for thrombolytic therapy. However, it's important to note that while zinc enhances the enzymatic activity, the isolated effects of zinc on blood clot breakdown remain somewhat unclear due to the enzyme's overall presence.
This research highlights the potential of the marine-derived enzyme and the role of zinc, suggesting that further studies could provide deeper insights into improving thrombolytic treatments. These findings could be significant for enhancing the safety and effectiveness of therapies designed for clot management.
Interestingly, the enzyme demonstrated a low level of hemolysis at just 2.60%, indicating that it could be a safer alternative for thrombolytic therapy. However, it's important to note that while zinc enhances the enzymatic activity, the isolated effects of zinc on blood clot breakdown remain somewhat unclear due to the enzyme's overall presence.
This research highlights the potential of the marine-derived enzyme and the role of zinc, suggesting that further studies could provide deeper insights into improving thrombolytic treatments. These findings could be significant for enhancing the safety and effectiveness of therapies designed for clot management.
Read More
9.5
We investigated how a new hemostatic agent, HEMO-IONIC®, which is enriched with zinc and made from calcium alginate, influences blood clotting and tissue repair. Our focus was on how this innovative compress can help control bleeding while also promoting healing after surgery.
In our study, we compared the effects of HEMO-IONIC with other common hemostatic products, like Surgicel® and TachoSil®. What we found was impressive: HEMO-IONIC not only effectively helped to achieve hemostasis, but it also supported the health of vascular endothelial cells, which are crucial for tissue repair.
Unlike Surgicel, which showed high cytotoxicity, and TachoSil, which inhibited cell migration, HEMO-IONIC promoted the migration of endothelial cells and increased angiogenesis—the formation of new blood vessels. This means that it not only helps stop bleeding but also enhances the body's natural repair processes by attracting essential healing cells and speeding up the maturation of the extracellular matrix.
Overall, we found that using HEMO-IONIC at the end of surgical procedures has long-term positive effects on every phase of tissue repair, making it a promising alternative to traditional hemostatic agents.
In our study, we compared the effects of HEMO-IONIC with other common hemostatic products, like Surgicel® and TachoSil®. What we found was impressive: HEMO-IONIC not only effectively helped to achieve hemostasis, but it also supported the health of vascular endothelial cells, which are crucial for tissue repair.
Unlike Surgicel, which showed high cytotoxicity, and TachoSil, which inhibited cell migration, HEMO-IONIC promoted the migration of endothelial cells and increased angiogenesis—the formation of new blood vessels. This means that it not only helps stop bleeding but also enhances the body's natural repair processes by attracting essential healing cells and speeding up the maturation of the extracellular matrix.
Overall, we found that using HEMO-IONIC at the end of surgical procedures has long-term positive effects on every phase of tissue repair, making it a promising alternative to traditional hemostatic agents.
Read More
8
We explored how zinc affects blood clotting, particularly through a substance called Zn@SiO nanocomposite. This material shows promise as a hemostatic agent, which means it helps stop bleeding by promoting the formation of stable blood clots.
During our analysis, we examined various aspects of how this nanocomposite interacts with blood. It activates specific factors in the coagulation cascade—the process our bodies use to form clots. With the presence of zinc in the material, we observed enhanced activation of these factors, leading to improved clot formation.
Our research involved synthesizing and characterizing the Zn@SiO nanocomposite using several methods, including XRD, FTIR, and HRTEM. We also tested its effects on red blood cell aggregation, platelet adhesion, and several vital clotting time measures. The results indicate that Zn@SiO has significant hemostatic properties, showing potential for use in surgeries and trauma care.
This study highlights the exciting role of zinc in optimizing hemostasis, making it a candidate worth considering for medical applications related to bleeding management.
During our analysis, we examined various aspects of how this nanocomposite interacts with blood. It activates specific factors in the coagulation cascade—the process our bodies use to form clots. With the presence of zinc in the material, we observed enhanced activation of these factors, leading to improved clot formation.
Our research involved synthesizing and characterizing the Zn@SiO nanocomposite using several methods, including XRD, FTIR, and HRTEM. We also tested its effects on red blood cell aggregation, platelet adhesion, and several vital clotting time measures. The results indicate that Zn@SiO has significant hemostatic properties, showing potential for use in surgeries and trauma care.
This study highlights the exciting role of zinc in optimizing hemostasis, making it a candidate worth considering for medical applications related to bleeding management.
Read More
8
We examined how zinc (Zn) impacts blood clotting, particularly focusing on its interaction with prostacyclin (PGI) signaling in platelets. The study revealed that about 17.3% of people worldwide experience some level of zinc deficiency, which can lead to impaired blood clotting and increased bleeding.
By conducting a series of experiments involving platelet aggregation and thrombus formation, we found that zinc chelators, which bind and remove zinc, enhanced the signaling pathway of PGI. This signaling is crucial because it helps platelets avoid becoming overly activated, thus reducing clot formation.
Interestingly, we observed that the presence of these zinc chelators resulted in either the breakdown of preformed clots in whole blood or the reversal of platelet spreading in isolated platelets. Moreover, our findings indicated that blocking adenylyl cyclase—an enzyme involved in PGI signaling—prevented the effects of zinc chelation, solidifying the idea that zinc plays a regulatory role in this process.
Ultimately, our research suggests that reducing zinc levels can amplify the effectiveness of PGI in controlling platelet activity and preventing excessive clotting. This could have important implications for individuals suffering from bleeding disorders or those at risk of blood clot-related complications.
By conducting a series of experiments involving platelet aggregation and thrombus formation, we found that zinc chelators, which bind and remove zinc, enhanced the signaling pathway of PGI. This signaling is crucial because it helps platelets avoid becoming overly activated, thus reducing clot formation.
Interestingly, we observed that the presence of these zinc chelators resulted in either the breakdown of preformed clots in whole blood or the reversal of platelet spreading in isolated platelets. Moreover, our findings indicated that blocking adenylyl cyclase—an enzyme involved in PGI signaling—prevented the effects of zinc chelation, solidifying the idea that zinc plays a regulatory role in this process.
Ultimately, our research suggests that reducing zinc levels can amplify the effectiveness of PGI in controlling platelet activity and preventing excessive clotting. This could have important implications for individuals suffering from bleeding disorders or those at risk of blood clot-related complications.
Read More
8
We observed a significant advance in our understanding of how zinc therapy can affect blood clotting, particularly with a compound called rutin. This study explored how zinc ions can be combined with rutin to enhance its aqueous solubility and therapeutic potential.
Rutin, a natural flavonoid found in various plants and foods, has been known for its ability to inhibit a protein called protein disulfide isomerase (PDI), which plays a role in blood clotting. However, we encountered challenges with rutin’s low solubility in water, which limits its effectiveness in therapeutic settings.
In this study, we found that when we chelated zinc ions with rutin, the resulting rutin:Zn complex showed a remarkable fourfold increase in solubility. More excitingly, this complex also exhibited a stronger inhibition of PDI activity compared to rutin alone.
In further testing with a murine model designed to induce arterial thrombosis, the rutin:Zn complex demonstrated a notable ability to slow down arterial occlusion without increasing bleeding risks. This suggests that zinc not only aids in solubility but also enhances the anti-thrombotic properties of rutin.
Overall, our findings indicate that combining zinc with certain flavonoids could be a promising strategy for elevating their benefits in combating blood clots.
Rutin, a natural flavonoid found in various plants and foods, has been known for its ability to inhibit a protein called protein disulfide isomerase (PDI), which plays a role in blood clotting. However, we encountered challenges with rutin’s low solubility in water, which limits its effectiveness in therapeutic settings.
In this study, we found that when we chelated zinc ions with rutin, the resulting rutin:Zn complex showed a remarkable fourfold increase in solubility. More excitingly, this complex also exhibited a stronger inhibition of PDI activity compared to rutin alone.
In further testing with a murine model designed to induce arterial thrombosis, the rutin:Zn complex demonstrated a notable ability to slow down arterial occlusion without increasing bleeding risks. This suggests that zinc not only aids in solubility but also enhances the anti-thrombotic properties of rutin.
Overall, our findings indicate that combining zinc with certain flavonoids could be a promising strategy for elevating their benefits in combating blood clots.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
2
Weakens stomach often
2 people found this helpful
Zinc hinders viral growth in the throat and respiratory tract, increasing blood leukocyte production which combats bacteria and viruses. This supplement is effective at the first sign of a cold but has a major drawback: it often irritates the stomach, causing discomfort after meals or on an empty stomach. I found another brand that doesn't have these side effects and would not recommend this one.
Read More
9
Significant health improvement
1 people found this helpful
After taking this supplement for a month, I've seen a notable improvement in my overall health. My immune system has strengthened as I haven't caught a cold or flu since starting it. Additionally, my blood clotting has improved, allowing for quicker healing of minor cuts and wounds. My hair feels thicker, and my skin appears clearer and brighter. It's a great quality product for enhancing overall health!
Read More
6
Supports immunity well
4 people found this helpful
An excellent form of zinc, it is chelated and absorbed effectively. We take one capsule daily during cold season with meals; on an empty stomach, it may cause headaches. We limit usage to a month and monitor zinc levels with blood tests to avoid excess. It aids immunity and reduces acne due to its anti-inflammatory properties. Recovery with zinc is quicker. Alongside C and D3, I boost mine and my family's immunity. Stay healthy and happy!
Read More
8
Zinc levels normalised
I took this during my pregnancy after receiving concerning bloodwork results from my OB-GYN. After retesting, my zinc levels were normal, which was a relief. The supplement has a pleasant taste and I experienced no adverse side effects.
Read More
7.5
Improved wound healing
4 people found this helpful
Due to low zinc levels, I experienced skin inflammation and slow wound healing, leading to severe hair loss. After a hospital-prescribed 10mg dose proved inadequate, I began taking a quality amino acid mixture alongside biotin. After just two weeks, my wound healing significantly improved, and I intend to continue with these effective products.
Read More
Frequently Asked Questions
9
Significant health improvement
1 people found this helpful
After taking this supplement for a month, I've seen a notable improvement in my overall health. My immune system has strengthened as I haven't caught a cold or flu since starting it. Additionally, my blood clotting has improved, allowing for quicker healing of minor cuts and wounds. My hair feels thicker, and my skin appears clearer and brighter. It's a great quality product for enhancing overall health!
7.5
Improved wound healing
4 people found this helpful
Due to low zinc levels, I experienced skin inflammation and slow wound healing, leading to severe hair loss. After a hospital-prescribed 10mg dose proved inadequate, I began taking a quality amino acid mixture alongside biotin. After just two weeks, my wound healing significantly improved, and I intend to continue with these effective products.
6
Supports immunity well
4 people found this helpful
An excellent form of zinc, it is chelated and absorbed effectively. We take one capsule daily during cold season with meals; on an empty stomach, it may cause headaches. We limit usage to a month and monitor zinc levels with blood tests to avoid excess. It aids immunity and reduces acne due to its anti-inflammatory properties. Recovery with zinc is quicker. Alongside C and D3, I boost mine and my family's immunity. Stay healthy and happy!
9.5
We explored the effects of a newly discovered fibrinolytic enzyme from the marine fungus Penicillium steckii KU1, particularly its interaction with zinc in the context of blood clot dissolution. This enzyme, which has a molecular weight of 12.6 kDa, is a plasmin-like protein that becomes more active in the presence of zinc. While it effectively dissolves blood clots, achieving complete dissolution in just 30 minutes with a specific concentration, we also observed that its activity is significantly inhibited by certain agents like EDTA.
Interestingly, the enzyme demonstrated a low level of hemolysis at just 2.60%, indicating that it could be a safer alternative for thrombolytic therapy. However, it's important to note that while zinc enhances the enzymatic activity, the isolated effects of zinc on blood clot breakdown remain somewhat unclear due to the enzyme's overall presence.
This research highlights the potential of the marine-derived enzyme and the role of zinc, suggesting that further studies could provide deeper insights into improving thrombolytic treatments. These findings could be significant for enhancing the safety and effectiveness of therapies designed for clot management.
Interestingly, the enzyme demonstrated a low level of hemolysis at just 2.60%, indicating that it could be a safer alternative for thrombolytic therapy. However, it's important to note that while zinc enhances the enzymatic activity, the isolated effects of zinc on blood clot breakdown remain somewhat unclear due to the enzyme's overall presence.
This research highlights the potential of the marine-derived enzyme and the role of zinc, suggesting that further studies could provide deeper insights into improving thrombolytic treatments. These findings could be significant for enhancing the safety and effectiveness of therapies designed for clot management.
8
We explored how zinc affects blood clotting, particularly through a substance called Zn@SiO nanocomposite. This material shows promise as a hemostatic agent, which means it helps stop bleeding by promoting the formation of stable blood clots.
During our analysis, we examined various aspects of how this nanocomposite interacts with blood. It activates specific factors in the coagulation cascade—the process our bodies use to form clots. With the presence of zinc in the material, we observed enhanced activation of these factors, leading to improved clot formation.
Our research involved synthesizing and characterizing the Zn@SiO nanocomposite using several methods, including XRD, FTIR, and HRTEM. We also tested its effects on red blood cell aggregation, platelet adhesion, and several vital clotting time measures. The results indicate that Zn@SiO has significant hemostatic properties, showing potential for use in surgeries and trauma care.
This study highlights the exciting role of zinc in optimizing hemostasis, making it a candidate worth considering for medical applications related to bleeding management.
During our analysis, we examined various aspects of how this nanocomposite interacts with blood. It activates specific factors in the coagulation cascade—the process our bodies use to form clots. With the presence of zinc in the material, we observed enhanced activation of these factors, leading to improved clot formation.
Our research involved synthesizing and characterizing the Zn@SiO nanocomposite using several methods, including XRD, FTIR, and HRTEM. We also tested its effects on red blood cell aggregation, platelet adhesion, and several vital clotting time measures. The results indicate that Zn@SiO has significant hemostatic properties, showing potential for use in surgeries and trauma care.
This study highlights the exciting role of zinc in optimizing hemostasis, making it a candidate worth considering for medical applications related to bleeding management.
8
We observed a significant advance in our understanding of how zinc therapy can affect blood clotting, particularly with a compound called rutin. This study explored how zinc ions can be combined with rutin to enhance its aqueous solubility and therapeutic potential.
Rutin, a natural flavonoid found in various plants and foods, has been known for its ability to inhibit a protein called protein disulfide isomerase (PDI), which plays a role in blood clotting. However, we encountered challenges with rutin’s low solubility in water, which limits its effectiveness in therapeutic settings.
In this study, we found that when we chelated zinc ions with rutin, the resulting rutin:Zn complex showed a remarkable fourfold increase in solubility. More excitingly, this complex also exhibited a stronger inhibition of PDI activity compared to rutin alone.
In further testing with a murine model designed to induce arterial thrombosis, the rutin:Zn complex demonstrated a notable ability to slow down arterial occlusion without increasing bleeding risks. This suggests that zinc not only aids in solubility but also enhances the anti-thrombotic properties of rutin.
Overall, our findings indicate that combining zinc with certain flavonoids could be a promising strategy for elevating their benefits in combating blood clots.
Rutin, a natural flavonoid found in various plants and foods, has been known for its ability to inhibit a protein called protein disulfide isomerase (PDI), which plays a role in blood clotting. However, we encountered challenges with rutin’s low solubility in water, which limits its effectiveness in therapeutic settings.
In this study, we found that when we chelated zinc ions with rutin, the resulting rutin:Zn complex showed a remarkable fourfold increase in solubility. More excitingly, this complex also exhibited a stronger inhibition of PDI activity compared to rutin alone.
In further testing with a murine model designed to induce arterial thrombosis, the rutin:Zn complex demonstrated a notable ability to slow down arterial occlusion without increasing bleeding risks. This suggests that zinc not only aids in solubility but also enhances the anti-thrombotic properties of rutin.
Overall, our findings indicate that combining zinc with certain flavonoids could be a promising strategy for elevating their benefits in combating blood clots.
4
We explored how zinc and iron ions influence the body’s ability to break down blood clots using a drug called tissue plasminogen activator (tPA). This study is particularly important due to the limited options available for treating acute ischemic strokes, where rapid clot removal is crucial.
Our research included laboratory tests and in vivo experiments to observe the effects of these metal ions on tPA-induced thrombolysis. We found that while zinc and iron appeared to inhibit this process, adding a metal ion chelator, EDTA, along with tPA significantly improved the efficiency of clot dissolution.
Interestingly, using zinc or iron by themselves did not show strong thrombolytic effects, but when combined with EDTA, the rate of reperfusion, which is the restoration of blood flow, drastically increased compared to using tPA alone. This suggests that ion chelation might not only make tPA more effective but could also potentially reduce side effects by lowering the dosage needed for treatment.
We did not find a strong independent benefit of zinc alone on its own for thrombolysis, but its role in combination with other agents like EDTA opens up new avenues for safer and more effective treatments for stroke patients.
Our research included laboratory tests and in vivo experiments to observe the effects of these metal ions on tPA-induced thrombolysis. We found that while zinc and iron appeared to inhibit this process, adding a metal ion chelator, EDTA, along with tPA significantly improved the efficiency of clot dissolution.
Interestingly, using zinc or iron by themselves did not show strong thrombolytic effects, but when combined with EDTA, the rate of reperfusion, which is the restoration of blood flow, drastically increased compared to using tPA alone. This suggests that ion chelation might not only make tPA more effective but could also potentially reduce side effects by lowering the dosage needed for treatment.
We did not find a strong independent benefit of zinc alone on its own for thrombolysis, but its role in combination with other agents like EDTA opens up new avenues for safer and more effective treatments for stroke patients.
References
- Kunhiraman S, Haridas M, Basheer SM, Chellappan S, Abdulhameed S. Least hemolytic, 12.6 kDa, plasmin-like fibrinolytic protease from marine Penicillium steckii KU1. Int J Biol Macromol. 2024;283:137854. doi:10.1016/j.ijbiomac.2024.137854
- M S M, Samal DB, Amirtraj J V, Subramanian S, Venkatasubbu GD. Enhanced coagulation cascade activation and styptic effects of Zn@SiO nanocomposite. Colloids Surf B Biointerfaces. 2024;239:113927. doi:10.1016/j.colsurfb.2024.113927
- Coupland CA, Naylor-Adamson L, Booth Z, Price TW, Gil HM, et al. Platelet zinc status regulates prostaglandin-induced signaling, altering thrombus formation. J Thromb Haemost. 2023;21:2545. doi:10.1016/j.jtha.2023.05.008
- Liao X, Ji P, Chi K, Chen X, Zhou Y, et al. Enhanced inhibition of protein disulfide isomerase and anti-thrombotic activity of a rutin derivative: rutin:Zn complex. RSC Adv. 2023;13:11464. doi:10.1039/d3ra01135f
- Ponsen AC, Proust R, Soave S, Mercier-Nomé F, Garcin I, et al. A new hemostatic agent composed of Zn-enriched Ca alginate activates vascular endothelial cells and promotes tissue repair . Bioact Mater. 2022;18:368. doi:10.1016/j.bioactmat.2022.01.049
- Yu X, Wang Z, Li YV. Metal ion chelation enhances tissue plasminogen activator (tPA)-induced thrombolysis: an in vitro and in vivo study. J Thromb Thrombolysis. 2022;53:291. doi:10.1007/s11239-021-02600-6
